Recombinant human N-acetylgalactosamine-6-sulfate sulfatase (GALNS) produced in the methylotrophic yeast Pichia pastoris

Mucopolysaccharidosis IV A (MPS IV A, Morquio A disease) is a lysosomal storage disease (LSD) produced by mutations on N-acetylgalactosamine-6-sulfate sulfatase (GALNS). Recently an enzyme replacement therapy (ERT) for this disease was approved using a recombinant enzyme produced in CHO cells. Previ...

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Pubblicato in:Sci Rep
Autori principali: Rodríguez-López, Alexander, Alméciga-Díaz, Carlos J., Sánchez, Jhonnathan, Moreno, Jefferson, Beltran, Laura, Díaz, Dennis, Pardo, Andrea, Ramírez, Aura María, Espejo-Mojica, Angela J., Pimentel, Luisa, Barrera, Luis A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932491/
https://ncbi.nlm.nih.gov/pubmed/27378276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29329
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