Lineage-Specific Early Differentiation of Human Embryonic Stem Cells Requires a G2 Cell Cycle Pause

Human embryonic stem cells (hESCs) have an abbreviated G1 phase of the cell cycle that allows rapid proliferation and maintenance of pluripotency. Lengthening of G1 corresponds to loss of pluripotency during differentiation. However, precise mechanisms that link alterations in the cell cycle and ear...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: VanOudenhove, Jennifer J., Grandy, Rodrigo A., Ghule, Prachi N., del Rio, Roxana, Lian, Jane B., Stein, Janet L., Zaidi, Sayyed K., Stein, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931987/
https://ncbi.nlm.nih.gov/pubmed/26946228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2352
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