Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling

The transition of human embryonic stem cells (hESCs) from pluripotency to lineage commitment is not fully understood, and a role for phenotypic transcription factors in the initial stages of hESC differentiation remains to be explored. From a screen of candidate factors, we found that RUNX1 is selec...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: VanOudenhove, Jennifer J., Medina, Ricardo, Ghule, Prachi N., Lian, Jane B., Stein, Janet L., Zaidi, Sayyed K., Stein, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106514/
https://ncbi.nlm.nih.gov/pubmed/27720906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.09.006
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