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Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres
Cyclin B-Cdk1 is a key mediator of mitotic entry, however little is known about its role in the separation of sister chromatids. Here we report that upon mitotic entry, Cdk1 specifically phosphorylates threonine 371 of TRF1, a telomere binding protein implicated in the regulation of sister telomere...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4931922/ https://ncbi.nlm.nih.gov/pubmed/21712819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1372 |
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