Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple mechanisms, including the inhibition of cyclo-oxygenases, modulation of NF-κB activity, and direct activation of AMPK. However, the full spectr...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Shirakawa, Kotaro, Wang, Lan, Man, Na, Maksimoska, Jasna, Sorum, Alexander W, Lim, Hyung W, Lee, Intelly S, Shimazu, Tadahiro, Newman, John C, Schröder, Sebastian, Ott, Melanie, Marmorstein, Ronen, Meier, Jordan, Nimer, Stephen, Verdin, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Human Biology and Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931907/
https://ncbi.nlm.nih.gov/pubmed/27244239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11156
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