Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPR (mt)

The mitochondrial matrix protease CLPP plays a central role in the activation of the mitochondrial unfolded protein response (UPR (mt)) in Caenorhabditis elegans. Far less is known about mammalian UPR (mt) signaling, although similar roles were assumed for central players, including CLPP. To better...

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Bibliografische gegevens
Gepubliceerd in:EMBO Rep
Hoofdauteurs: Seiferling, Dominic, Szczepanowska, Karolina, Becker, Christina, Senft, Katharina, Hermans, Steffen, Maiti, Priyanka, König, Tim, Kukat, Alexandra, Trifunovic, Aleksandra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
Onderwerpen:
Scientific Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931557/
https://ncbi.nlm.nih.gov/pubmed/27154400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642077
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