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MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

The circadian clock and the cell cycle are major cellular systems that organize global physiology in temporal fashion. It seems conceivable that the potentially conflicting programs are coordinated. We show here that overexpression of MYC in U2OS cells attenuates the clock and conversely promotes ce...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Shostak, Anton, Ruppert, Bianca, Ha, Nati, Bruns, Philipp, Toprak, Umut H., Eils, Roland, Schlesner, Matthias, Diernfellner, Axel, Brunner, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931031/
https://ncbi.nlm.nih.gov/pubmed/27339797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11807
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