High Glucose-Induced PC12 Cell Death by Increasing Glutamate Production and Decreasing Methyl Group Metabolism

Objective. High glucose- (HG-) induced neuronal cell death is responsible for the development of diabetic neuropathy. However, the effect of HG on metabolism in neuronal cells is still unclear. Materials and Methods. The neural-crest derived PC12 cells were cultured for 72 h in the HG (75 mM) or con...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Chen, Minjiang, Zheng, Hong, Wei, Tingting, Wang, Dan, Xia, Huanhuan, Zhao, Liangcai, Ji, Jiansong, Gao, Hongchang
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930799/
https://ncbi.nlm.nih.gov/pubmed/27413747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/4125731
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