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Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motoneurons. Hyperexcitability and excitotoxicity have been implicated in the early pathogenesis of ALS. Studies addressing excitotoxic motoneuron death and intracellular Ca(2+) overload have most...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Chang, Qing, Martin, Lee J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930677/
https://ncbi.nlm.nih.gov/pubmed/27151771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.04.009
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