Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History

Estrogen conjugates with a polyamidoamine (PAMAM) dendrimer have shown remarkably selective regulation of the non-genomic actions of estrogens in target cells. In response to pH changes, however, these estrogen-dendrimer conjugates (EDCs) display a major morphological transition that alters the acce...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Kim, Sung Hoon, Madak-Erdogan, Zeynep, Bae, Sung Chul, Carlson, Kathryn E., Mayne, Christopher G., Granick, Steve, Katzenellenbogen, Benita S., Katzenellenbogen, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929999/
https://ncbi.nlm.nih.gov/pubmed/26186415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05952
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