The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model

Humans encode seven APOBEC3 proteins (A–H), with A3G, 3F and 3H as the major factors restricting HIV-1 replication. HIV-1, however, encodes Vif, which counteracts A3 proteins by chaperoning them to the proteasome where they are degraded. Vif polymorphisms found in HIV-1s isolated from infected patie...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Cadena, Cristhian, Stavrou, Spyridon, Manzoni, Tomaz, Iyer, Shilpa S., Bibollet-Ruche, Frederic, Zhang, Weiyu, Hahn, Beatrice H., Browne, Edward P., Ross, Susan R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929759/
https://ncbi.nlm.nih.gov/pubmed/27363431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-016-0280-y
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