Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing compl...

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Publicado no:Sci Rep
Main Authors: Stock, Kristin, Estrada, Marta F., Vidic, Suzana, Gjerde, Kjersti, Rudisch, Albin, Santo, Vítor E., Barbier, Michaël, Blom, Sami, Arundkar, Sharath C., Selvam, Irwin, Osswald, Annika, Stein, Yan, Gruenewald, Sylvia, Brito, Catarina, van Weerden, Wytske, Rotter, Varda, Boghaert, Erwin, Oren, Moshe, Sommergruber, Wolfgang, Chong, Yolanda, de Hoogt, Ronald, Graeser, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929472/
https://ncbi.nlm.nih.gov/pubmed/27364600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28951
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