Alzheimer’s disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules

Although β-amyloid (Aβ) may be the primary driver of Alzheimer’s disease (AD) pathology, accumulation of pathological tau correlates with dementia in AD patients. Thus, the prevention/inhibition of AD may require vaccine/s targeting Aβ and tau simultaneously or sequentially. Since high antibody tite...

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Publicat a:Sci Rep
Autors principals: Davtyan, Hayk, Zagorski, Karen, Rajapaksha, Harinda, Hovakimyan, Armine, Davtyan, Arpine, Petrushina, Irina, Kazarian, Konstantin, Cribbs, David H., Petrovsky, Nikolai, Agadjanyan, Michael G., Ghochikyan, Anahit
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929459/
https://ncbi.nlm.nih.gov/pubmed/27363809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28912
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