Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway

This study investigated the function of a chloride channel blocker, DIDS. Both in vitro and in vivo studies found that DIDS significantly inhibits lipopolysaccharide (LPS)-induced release of proin flammatory cytokines. Here, we show that DIDS inhibits LPS-induced inflammation, as shown by downregula...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Xiang, Nan-lin, Liu, Jun, Liao, Yun-jian, Huang, You-wei, Wu, Zheng, Bai, Zhi-quan, Lin, Xi, Zhang, Jian-hua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929440/
https://ncbi.nlm.nih.gov/pubmed/27363391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27583
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