A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer

PURPOSE: Glucocorticoid receptor (GR) overexpression is associated with poor prognosis ER-negative breast cancer. GR antagonism with mifepristone increases chemotherapy-induced breast cancer cell death, therefore we conducted a phase I clinical trial of mifepristone and nab-paclitaxel in advanced br...

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Bibliografiska uppgifter
I publikationen:Springerplus
Huvudupphovsmän: Nanda, Rita, Stringer-Reasor, Erica M., Saha, Poornima, Kocherginsky, Masha, Gibson, Jean, Libao, Bernadette, Hoffman, Philip C., Obeid, Elias, Merkel, Douglas E., Khramtsova, Galina, Skor, Maxwell, Krausz, Thomas, Cohen, Ronald N., Ratain, Mark J., Fleming, Gini F., Conzen, Suzanne D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2016
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929099/
https://ncbi.nlm.nih.gov/pubmed/27386391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-016-2457-1
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