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Mechanisms of modulation of cytokine release by human cord blood monocytes exposed to high concentrations of caffeine

BACKGROUND: Serum caffeine concentrations >20µg/mL (100 µM) in infants treated for apnea of prematurity increases TNF-α and decreases IL-10, change that perhaps is linked to co-morbidities. We hypothesize that this pro-inflammatory cytokine profile may be linked to differential binding of caffein...

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Bibliographic Details
Published in:Pediatr Res
Main Authors: Chavez-Valdez, Raul, Ahlawat, Rajni, Wills-Karp, Marsha, Gauda, Estelle B.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929021/
https://ncbi.nlm.nih.gov/pubmed/26982450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2016.50
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