Tagging methyl-CpG-binding domain proteins reveals different spatiotemporal expression and supports distinct functions

AIM: DNA methylation is recognized by methyl-CpG-binding domain (MBD) proteins. Multiple MBDs are linked to neurodevelopmental disorders in humans and mice. However, the functions of MBD2 are poorly understood. We characterized Mbd2 knockout mice and determined spatiotemporal expression of MBDs and...

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Detalhes bibliográficos
Publicado no:Epigenomics
Main Authors: Wood, Kathleen H, Johnson, Brian S, Welsh, Sarah A, Lee, Jun Y, Cui, Yue, Krizman, Elizabeth, Brodkin, Edward S, Blendy, Julie A, Robinson, Michael B, Bartolomei, Marisa S, Zhou, Zhaolan
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928502/
https://ncbi.nlm.nih.gov/pubmed/27066839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/epi-2015-0004
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