PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease

Phosphodiesterase 5 (PDE5) is a critical component of the cGMP-PKG axis of cellular signaling in neurons, and inhibition of PDE5 has been shown to be therapeutic in a wide range of neurologic conditions in animal models. However, enthusiasm for PDE5 inhibitors in humans is limited by data suggesting...

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Vydáno v:J Alzheimers Dis
Hlavní autoři: Teich, Andrew F., Sakurai, Mikako, Patel, Mitesh, Holman, Cameron, Saeed, Faisal, Fiorito, Jole, Arancio, Ottavio
Médium: Artigo
Jazyk:Inglês
Vydáno: IOS Press 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927884/
https://ncbi.nlm.nih.gov/pubmed/26967220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-151104
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