Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

A series of bicyclams have been shown to be potent and selective inhibitors of human immunodeficiency virus (HIV). The compounds are inhibitory to the replication of various HIV-1 and HIV-2 strains in various human T-cell systems, including peripheral blood lymphocytes, at 0.14-1.4 microM, without b...

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Bibliographic Details
Main Authors: De Clercq, E, Yamamoto, N, Pauwels, R, Baba, M, Schols, D, Nakashima, H, Balzarini, J, Debyser, Z, Murrer, B A, Schwartz, D
Format: Artigo
Language:Inglês
Published: 1992
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC49276/
https://ncbi.nlm.nih.gov/pubmed/1608936
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