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Renal 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion
A positional isomer of 3′,5′-cAMP, 2′,3′-cAMP, is produced by kidneys in response to energy depletion, and renal 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) metabolizes 2′,3′-cAMP to 2′-AMP; 2′,3′-cAMP is a potent opener of mitochondrial permeability transition pores (mPTPs), which can sti...
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| Publicado no: | J Am Soc Nephrol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4926972/ https://ncbi.nlm.nih.gov/pubmed/26574047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015040397 |
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