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Biophysical constraints of optogenetic inhibition at presynaptic terminals

We investigated the efficacy of optogenetic inhibition at presynaptic terminals using halorhodopsin, archaerhodopsin and chloride-conducting channelrhodopsins. Precisely timed activation of both archaerhodopsin and halorhodpsin at presynaptic terminals attenuated evoked release. However, sustained a...

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發表在:Nat Neurosci
Main Authors: Mahn, Mathias, Prigge, Matthias, Ron, Shiri, Levy, Rivka, Yizhar, Ofer
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926958/
https://ncbi.nlm.nih.gov/pubmed/26950004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4266
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