Synthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy

Rational assembly of small molecule libraries for purposes of drug discovery requires an efficient approach in which the synthesis of bioactive compounds is enabled so that numerous structurally related compounds of a similar basic formulation can be derived. Here, we describe (4 + 3) and (3 + 2) in...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Chepurny, Oleg G., Leech, Colin A., Tomanik, Martin, DiPoto, Maria C., Li, Hui, Han, Xinping, Meng, Qinghe, Cooney, Robert N., Wu, Jimmy, Holz, George G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926213/
https://ncbi.nlm.nih.gov/pubmed/27352904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28934
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