The NLRP3/Caspase-1/Interleukin-1β Axis Is Active in Human Lumbar Cartilaginous Endplate Degeneration

BACKGROUND: Modic changes are the MRI signal changes of degenerative lumbar vertebral endplate and which lead to or accelerate intervertebral disc degeneration. NLRP3, caspase-1, and interleukin-1β (IL-1β) play a pivotal role in the pathogenesis of many inflammatory diseases, such as osteoarthritis....

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Udgivet i:Clin Orthop Relat Res
Main Authors: Tang, Pan, Zhu, Ren, Ji, Wei-Ping, Wang, Ji-Ying, Chen, Shuai, Fan, Shun-Wu, Hu, Zhi-Jun
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2016
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925417/
https://ncbi.nlm.nih.gov/pubmed/27146654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11999-016-4866-4
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