Processive Incorporation of Deoxynucleoside Triphosphate Analogs by Single-Molecule DNA Polymerase I (Klenow Fragment) Nanocircuits

DNA polymerases exhibit a surprising tolerance for analogs of deoxyribonucleoside triphosphates (dNTPs), despite the enzymes’ highly evolved mechanisms for the specific recognition and discrimination of native dNTPs. Here, individual DNA Polymerase I Klenow Fragment (KF) molecules were tethered to a...

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Publicado en:J Am Chem Soc
Main Authors: Pugliese, Kaitlin M., Gul, O. Tolga, Choi, Yongki, Olsen, Tivoli J., Sims, Patrick C., Collins, Philip G., Weiss, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925316/
https://ncbi.nlm.nih.gov/pubmed/26147714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b02074
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