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Obesity enhances sepsis induced liver inflammation and injury in mice

OBJECTIVE: How obesity affects the response to sepsis is not completely understood. We hypothesize that obesity alters adipose and hepatic tissue inflammation through STAT3 activation. METHODS: Male C57BL/6 mice at six-weeks of age were randomized to a high-fat (HFD) (60% kcal fat) or normal diet (N...

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Podrobná bibliografie
Vydáno v:Obesity (Silver Spring)
Hlavní autoři: Kaplan, Jennifer M., Nowell, Marchele, Lahni, Patrick, Shen, Hui, Shanmukhappa, Shiva K., Zingarelli, Basilia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925204/
https://ncbi.nlm.nih.gov/pubmed/27172993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.21504
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