Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma

We investigated the use of cucurbitacin B, a plant-derived tetracyclic triterpenoid, as a single agent or in combination with methotrexate (MTX) for human osteosarcoma (OS) treatment. Cucurbitacin B showed antiproliferative activity against seven human OS cell lines in vitro accompanying G2/M cell c...

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Udgivet i:Cancer Lett
Main Authors: Lee, Dhong Hyun, Thoennissen, Nils H., Goff, Catherine, Iwanski, Gabriela B., Forscher, Charles, Doan, Ngan B., Said, Jonathan W., Koeffler, H. Phillip
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925102/
https://ncbi.nlm.nih.gov/pubmed/21440986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.03.001
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