Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease

After postoperative deaths in children who were prescribed codeine, several pediatric hospitals have removed it from their formularies. These deaths were attributed to atypical cytochrome P450 2D6 (CYP2D6) pharmacogenetics, which is also implicated in poor analgesic response. Because codeine is ofte...

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Detalhes bibliográficos
Publicado no:Pediatrics
Main Authors: Gammal, Roseann S., Crews, Kristine R., Haidar, Cyrine E., Hoffman, James M., Baker, Donald K., Barker, Patricia J., Estepp, Jeremie H., Pei, Deqing, Broeckel, Ulrich, Wang, Winfred, Weiss, Mitchell J., Relling, Mary V., Hankins, Jane
Formato: Artigo
Idioma:Inglês
Publicado em: American Academy of Pediatrics 2016
Assuntos:
Special Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925073/
https://ncbi.nlm.nih.gov/pubmed/27335380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1542/peds.2015-3479
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