Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease

After postoperative deaths in children who were prescribed codeine, several pediatric hospitals have removed it from their formularies. These deaths were attributed to atypical cytochrome P450 2D6 (CYP2D6) pharmacogenetics, which is also implicated in poor analgesic response. Because codeine is ofte...

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Dettagli Bibliografici
Pubblicato in:Pediatrics
Autori principali: Gammal, Roseann S., Crews, Kristine R., Haidar, Cyrine E., Hoffman, James M., Baker, Donald K., Barker, Patricia J., Estepp, Jeremie H., Pei, Deqing, Broeckel, Ulrich, Wang, Winfred, Weiss, Mitchell J., Relling, Mary V., Hankins, Jane
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Academy of Pediatrics 2016
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Special Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925073/
https://ncbi.nlm.nih.gov/pubmed/27335380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1542/peds.2015-3479
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