The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma

Deletion of CDKN2A (p16) or amplification of CCND1 (cyclin D1) occurs commonly in head and neck squamous cell carcinoma (HNSCC) and induces sustained cyclin-dependent kinase (CDK) 4/6 activation. Here, we report the antiproliferative activity of LY2835219, a selective CDK4/6 inhibitor through inhibi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ku, Bo Mi, Yi, Seong Yoon, Koh, Jiae, Bae, Yeon-Hee, Sun, Jong-Mu, Lee, Se-hoon, Ahn, Jin Seok, Park, Keunchil, Ahn, Myung-Ju
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924753/
https://ncbi.nlm.nih.gov/pubmed/26909611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7543
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