Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes

Hypoxia-inducible factor-1 alpha (HIF-1α) is over-expressed in many cancers including pancreatic ductal adenocarcinoma (PDAC) and correlated with poor prognosis. We aim to determine the effect of germline genetic variants on the regulation of the homeostasis of the miRNA-gene regulatory loop in HIF1...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Wang, Xiuchao, Ren, He, Zhao, Tiansuo, Ma, Weidong, Dong, Jie, Zhang, Shengjie, Xin, Wen, Yang, Shengyu, Jia, Li, Hao, Jihui
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924673/
https://ncbi.nlm.nih.gov/pubmed/26872370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7263
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