Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes

Hypoxia-inducible factor-1 alpha (HIF-1α) is over-expressed in many cancers including pancreatic ductal adenocarcinoma (PDAC) and correlated with poor prognosis. We aim to determine the effect of germline genetic variants on the regulation of the homeostasis of the miRNA-gene regulatory loop in HIF1...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Wang, Xiuchao, Ren, He, Zhao, Tiansuo, Ma, Weidong, Dong, Jie, Zhang, Shengjie, Xin, Wen, Yang, Shengyu, Jia, Li, Hao, Jihui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924673/
https://ncbi.nlm.nih.gov/pubmed/26872370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7263
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