Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor

Interleukin-17 (IL-17) plays important roles in inflammation, autoimmune diseases, and some cancers. Obese people are in a chronic inflammatory state with increased serum levels of IL-17, insulin, and insulin-like growth factor 1 (IGF1). How these factors contribute to the chronic inflammatory statu...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Liu, Sen, Zhang, Qiuyang, Chen, Chong, Ge, Dongxia, Qu, Yine, Chen, Rongyi, Fan, Yi-Ming, Li, Nan, Tang, Wendell W., Zhang, Wensheng, Zhang, Kun, Wang, Alun R., Rowan, Brian G., Hill, Steven M., Sartor, Oliver, Abdel, Asim B., Myers, Leann, Lin, Qishan, You, Zongbing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924668/
https://ncbi.nlm.nih.gov/pubmed/26871944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7296
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