Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis

Hematopoietic stem and progenitor cell (HSPC) homeostasis declines with age, leading to impaired hematopoiesis. Mesenchymal stromal cells (MSC) are critical components of the bone marrow niche and key regulators of the balance between HSPC proliferation and quiescence. Accrual of DNA damage, a hallm...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: O'Hagan-Wong, Kelsey, Nadeau, Stéphanie, Carrier-Leclerc, Audrey, Apablaza, Felipe, Hamdy, Reggie, Shum-Tim, Dominique, Rodier, Francis, Colmegna, Inés
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper: Gerotarget (Focus on Aging)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924641/
https://ncbi.nlm.nih.gov/pubmed/26934440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7690
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