Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis

Hematopoietic stem and progenitor cell (HSPC) homeostasis declines with age, leading to impaired hematopoiesis. Mesenchymal stromal cells (MSC) are critical components of the bone marrow niche and key regulators of the balance between HSPC proliferation and quiescence. Accrual of DNA damage, a hallm...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: O'Hagan-Wong, Kelsey, Nadeau, Stéphanie, Carrier-Leclerc, Audrey, Apablaza, Felipe, Hamdy, Reggie, Shum-Tim, Dominique, Rodier, Francis, Colmegna, Inés
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2016
Aiheet:
Research Paper: Gerotarget (Focus on Aging)
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924641/
https://ncbi.nlm.nih.gov/pubmed/26934440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7690
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