Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis

Hematopoietic stem and progenitor cell (HSPC) homeostasis declines with age, leading to impaired hematopoiesis. Mesenchymal stromal cells (MSC) are critical components of the bone marrow niche and key regulators of the balance between HSPC proliferation and quiescence. Accrual of DNA damage, a hallm...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: O'Hagan-Wong, Kelsey, Nadeau, Stéphanie, Carrier-Leclerc, Audrey, Apablaza, Felipe, Hamdy, Reggie, Shum-Tim, Dominique, Rodier, Francis, Colmegna, Inés
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924641/
https://ncbi.nlm.nih.gov/pubmed/26934440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7690
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