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Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer

Treatment of ErbB2-overexpressing BT474 and MDA-MB-453 breast cancer cells with 1 to 10 μmol/L betulinic acid inhibited cell growth, induced apoptosis, downregulated specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4, and decreased expression of ErbB2. Individual or combined knockdown...

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Foilsithe in:Mol Cancer Ther
Main Authors: Liu, Xinyi, Jutooru, Indira, Lei, Ping, Kim, KyoungHyun, Lee, Syng-ook, Brents, Lisa K., Prather, Paul L., Safe, Stephen
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924623/
https://ncbi.nlm.nih.gov/pubmed/22553354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0026
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