Guanine-rich sequences inhibit proofreading DNA polymerases

DNA polymerases with proofreading activity are important for accurate amplification of target DNA. Despite numerous efforts have been made to improve the proofreading DNA polymerases, they are more susceptible to be failed in PCR than non-proofreading DNA polymerases. Here we showed that proofreadin...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhu, Xiao-Jing, Sun, Shuhui, Xie, Binghua, Hu, Xuemei, Zhang, Zunyi, Qiu, Mengsheng, Dai, Zhong-Min
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923904/
https://ncbi.nlm.nih.gov/pubmed/27349576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28769
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