Altering the Substrate Specificity of Organophosphorus Hydrolase for Enhanced Hydrolysis of Chlorpyrifos

Chlorpyrifos is one of the most popular pesticides used for agriculture crop protection, and widespread contamination is a potential concern. However, chlorpyrifos is hydrolyzed almost 1,000-fold slower than the preferred substrate, paraoxon, by organophosphorus hydrolase (OPH), an enzyme that can d...

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Bibliographic Details
Published in:Appl Environ Microbiol
Main Authors: Cho, Catherine Mee-Hie, Mulchandani, Ashok, Chen, Wilfred
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2004
Subjects:
Physiology and Biotechnology
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC492387/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15294802/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.70.8.4681-4685.2004
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