Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation

The lymphatic vasculature is essential for maintaining interstitial fluid homeostasis, and dysfunctional lymphangiogenesis contributes to various pathological processes, including inflammatory disease and tumor metastasis. Mutations in FOXC2 are dominantly associated with late-onset lymphedema; howe...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Fatima, Anees, Wang, Ying, Uchida, Yutaka, Norden, Pieter, Liu, Ting, Culver, Austin, Dietz, William H., Culver, Ford, Millay, Meredith, Mukouyama, Yoh-suke, Kume, Tsutomu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922698/
https://ncbi.nlm.nih.gov/pubmed/27214551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80465
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