IL-15 promotes activation and expansion of CD8(+) T cells in HIV-1 infection

In HIV-1–infected patients, increased numbers of circulating CD8(+) T cells are linked to increased risk of morbidity and mortality. Here, we identified a bystander mechanism that promotes CD8 T cell activation and expansion in untreated HIV-1–infected patients. Compared with healthy controls, untre...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Younes, Souheil-Antoine, Freeman, Michael L., Mudd, Joseph C., Shive, Carey L., Reynaldi, Arnold, Panigrahi, Soumya, Estes, Jacob D., Deleage, Claire, Lucero, Carissa, Anderson, Jodi, Schacker, Timothy W., Davenport, Miles P., McCune, Joseph M., Hunt, Peter W., Lee, Sulggi A., Serrano-Villar, Sergio, Debernardo, Robert L., Jacobson, Jeffrey M., Canaday, David H., Sekaly, Rafick-Pierre, Rodriguez, Benigno, Sieg, Scott F., Lederman, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922693/
https://ncbi.nlm.nih.gov/pubmed/27322062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85996
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