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Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation

Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established treatment for the motor symptoms of Parkinson's disease (PD). However, the mechanisms of action of DBS are unknown. Random temporal patterns of DBS are less effective than regular DBS, but the neuronal basis for this depen...

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Detalhes bibliográficos
Publicado no:J Neurophysiol
Main Authors: McConnell, George C., So, Rosa Q., Grill, Warren M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922603/
https://ncbi.nlm.nih.gov/pubmed/26961105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00822.2015
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