Evolution of the Transmission-Blocking Vaccine Candidates Pvs28 and Pvs25 in Plasmodium vivax: Geographic Differentiation and Evidence of Positive Selection

Transmission-blocking (TB) vaccines are considered an important tool for malaria control and elimination. Among all the antigens characterized as TB vaccines against Plasmodium vivax, the ookinete surface proteins Pvs28 and Pvs25 are leading candidates. These proteins likely originated by a gene dup...

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Publicat a:PLoS Negl Trop Dis
Autors principals: Chaurio, Ricardo A., Pacheco, M. Andreína, Cornejo, Omar E., Durrego, Ester, Stanley, Craig E., Castillo, Andreína I., Herrera, Sócrates, Escalante, Ananias A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922550/
https://ncbi.nlm.nih.gov/pubmed/27347876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004786
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