Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure

Dopamine D2 receptor (DRD2) deficiency increases renal inflammation and blood pressure in mice. We show here that long-term renal-selective silencing of Drd2 using siRNA increases renal expression of proinflammatory and profibrotic factors and blood pressure in mice. To determine the effects of rena...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Konkalmatt, Prasad R., Asico, Laureano D., Zhang, Yanrong, Yang, Yu, Drachenberg, Cinthia, Zheng, Xiaoxu, Han, Fei, Jose, Pedro A., Armando, Ines
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922424/
https://ncbi.nlm.nih.gov/pubmed/27358912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85888
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