Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure

Dopamine D2 receptor (DRD2) deficiency increases renal inflammation and blood pressure in mice. We show here that long-term renal-selective silencing of Drd2 using siRNA increases renal expression of proinflammatory and profibrotic factors and blood pressure in mice. To determine the effects of rena...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Konkalmatt, Prasad R., Asico, Laureano D., Zhang, Yanrong, Yang, Yu, Drachenberg, Cinthia, Zheng, Xiaoxu, Han, Fei, Jose, Pedro A., Armando, Ines
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922424/
https://ncbi.nlm.nih.gov/pubmed/27358912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85888
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