IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction

Heart disease is a leading cause of death in adults. Here, we show that a few days after coronary artery ligation and reperfusion, the ischemia-injured heart elaborates the cardioprotective polypeptide, insulin-like growth factor-1 (IGF-1), which activates IGF-1 receptor prosurvival signaling and im...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tejada, Thor, Tan, Lin, Torres, Rebecca A., Calvert, John W., Lambert, Jonathan P., Zaidi, Madiha, Husain, Murtaza, Berce, Maria D., Naib, Hussain, Pejler, Gunnar, Abrink, Magnus, Graham, Robert M., Lefer, David J., Naqvi, Nawazish, Husain, Ahsan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922143/
https://ncbi.nlm.nih.gov/pubmed/27274047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603127113
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