Novel Transgenic Mouse Models Develop Retinal Changes Associated with Early Diabetic Retinopathy Similar to Those Observed in Rats with Diabetes Mellitus

Retinal capillary pericyte degeneration has been linked to aldose reductase (AR) activity in diabetic retinopathy (DR). Since the development of DR in mice and rats has been reported to differ and that this may be linked to differences in retinal sorbitol levels, we have established new murine model...

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Udgivet i:Exp Eye Res
Main Authors: Guo, Changmei, Zhang, Zifeng, Zhang, Peng, Makita, Jun, Kawada, Hiroyoshi, Blessing, Karen, Kador, Peter F.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922005/
https://ncbi.nlm.nih.gov/pubmed/24370601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2013.12.009
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