Novel Transgenic Mouse Models Develop Retinal Changes Associated with Early Diabetic Retinopathy Similar to Those Observed in Rats with Diabetes Mellitus

Retinal capillary pericyte degeneration has been linked to aldose reductase (AR) activity in diabetic retinopathy (DR). Since the development of DR in mice and rats has been reported to differ and that this may be linked to differences in retinal sorbitol levels, we have established new murine model...

Full description

Saved in:
Bibliographic Details
Published in:Exp Eye Res
Main Authors: Guo, Changmei, Zhang, Zifeng, Zhang, Peng, Makita, Jun, Kawada, Hiroyoshi, Blessing, Karen, Kador, Peter F.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922005/
https://ncbi.nlm.nih.gov/pubmed/24370601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2013.12.009
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items