Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene

RATIONALE: Mutations in desmosome proteins cause arrhythmogenic cardiomyopathy (AC), a disease characterized by excess myocardial fibro-adipocytes. Cellular origin(s) of fibro-adipocytes in AC is unknown. OBJECTIVE: To identify the cellular origin of adipocytes in AC. METHODS AND RESULTS: Human and...

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Vydáno v:Circ Res
Hlavní autoři: Lombardi, Raffaella, Chen, Suet Nee, Ruggiero, Alessandra, Gurha, Priyatansh, Czernuszewicz, Grazyna Z., Willerson, James T., Marian, Ali J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920717/
https://ncbi.nlm.nih.gov/pubmed/27121621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.308136
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