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2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration

The correct migration and axon extension of neurons in the developing nervous system is essential for the appropriate wiring and function of neural networks. Here, we report that O-sulfotransferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to regulate neur...

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Bibliografski detalji
Izdano u:Development
Glavni autori: Tillo, Miguel, Charoy, Camille, Schwarz, Quenten, Maden, Charlotte H., Davidson, Kathryn, Fantin, Alessandro, Ruhrberg, Christiana
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920156/
https://ncbi.nlm.nih.gov/pubmed/27048738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.126854
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