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2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration

The correct migration and axon extension of neurons in the developing nervous system is essential for the appropriate wiring and function of neural networks. Here, we report that O-sulfotransferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to regulate neur...

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Foilsithe in:Development
Main Authors: Tillo, Miguel, Charoy, Camille, Schwarz, Quenten, Maden, Charlotte H., Davidson, Kathryn, Fantin, Alessandro, Ruhrberg, Christiana
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists Ltd 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920156/
https://ncbi.nlm.nih.gov/pubmed/27048738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.126854
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