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A novel Drosophila model of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects

Transactive response DNA-binding protein 43 kDa (TDP-43, also known as TBPH in Drosophila melanogaster and TARDBP in mammals) is the main protein component of the pathological inclusions observed in neurons of patients affected by different neurodegenerative disorders, including amyotrophic lateral...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Dis Model Mech
Κύριοι συγγραφείς: Langellotti, Simona, Romano, Valentina, Romano, Giulia, Klima, Raffaella, Feiguin, Fabian, Cragnaz, Lucia, Romano, Maurizio, Baralle, Francisco E.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Company of Biologists Ltd 2016
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920146/
https://ncbi.nlm.nih.gov/pubmed/27101846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.023382
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