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TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity
Recent studies have shown that the range of affinities of T cell receptors (TCRs) against non-mutated cancer peptide/class I complexes are lower than TCR affinities for foreign antigens. Raising the affinity of TCRs for optimal activity of CD8 T cells, and for recruitment of CD4 T cell activity agai...
Shranjeno v:
| izdano v: | Curr Opin Immunol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4920053/ https://ncbi.nlm.nih.gov/pubmed/25618219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2015.01.003 |
| Oznake: |
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